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I was influenced by the contrast between traditional and modern Japanese culture. Although renowned for its sterile social conduct and lack of intimacy, bathhouses and onsens remain a necessary part of their day. I thought it was beautiful that after a day at work, everyone strips down to their vulnerable human form to participate in a primitive event of washing.
TAZ, a WW-domain-containing transcriptional co-activator, is important for development of various tissues in mammals. Recently, TAZ has been found to be overexpressed in some types of human cancers. However, the role of TAZ in glioblastoma remains unclear.
Electronic address: shenke hust. Electronic address: xzhang hust. Renal cell carcinomas are a group of most common renal malignancies whose clinical intervention is complicated by the lack of early diagnosis and reliable prognosis biomarkers, insensitive radiotherapy and chemotherapy and expensive molecular-targeted drugs. Transcriptional coactivator TAZ has been implicated in the formation and development of various malignancies.
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Therefore, there is an urgent need to identify new therapeutic drug targets for successful treatment. Mounting evidence suggest that lung tumorigenesis is mostly driven by CSC or tumor initiating cells TICs that are more aggressive metastatic and refractory to conventional chemotherapeutics [ 3 ]. Therefore, identification of genes responsible for the development and maintenance of lung CSC phenotypes is critical for the development of drugs specifically targeting CSCs for successful lung cancer therapy.
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